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个人信息Personal Information
教授
教师英文名称：DOU Weibei
教师拼音名称：douweibei
办公地点：清华大学罗姆楼4-102
联系方式：Email: douwb@tsinghua.edu.cn； Tel: 010-62781703
学位：博士学位
毕业院校：电子科技大学学士、法国雷恩大学硕士、法国卡昂大学博士
Effects of reactive oxygen species on metabolism monitored by longitudinal H-1 single voxel MRS follow-up in patients with mitochondrial disease or cerebral tumors
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DOI码：10.1088/1742-6596/261/1/012011
发表刊物：COST CHEMISTRY CM0603-MELUSYN JOINT MEETING: DAMAGES INDUCED IN BIOMOLECULES BY LOW AND HIGH ENERGY RADIATIONS
摘要：Free radicals, or Reactive Oxygen Species (ROS), have an effect on energy and glycolytic metabolism, mitochondrial function, lipid metabolism, necrosis and apoptosis, cell proliferation, and infiltration. These changes could be monitored longitudinally (every 4 months over 6 years) in humans with glial brain tumors (low and high grade) after therapy, using conventional magnetic resonance imaging (MRI) and spectroscopy (MRS) and MR perfusion. Some examples of early clinical data from longitudinal follow-up monitoring in humans of energy and glycolytic metabolism, lipid metabolism, necrosis, proliferation, and infiltration measured by conventional MRI, MRS and perfusion, and positron emission tomography (PET) are shown in glial brain tumors after therapy. Despite the difficulty, the variability and unknown factors, these repeated measurements give us a better insight into the nature of the different processes, tumor progression and therapeutic response.
合写作者：Collet, Guillamo, J. S., Hossu, G., Lacombe, Gauduel, Y. A., Levin, C. Houee, Dou, W., Ruan, Barre, L., Rioult, Derlon, J. M., Lechapt-Zalcman, E., Valable, S., Chapon, Courtheoux, P., Fong, V., Kauffmann, F.,杨新辉,舒海燕,曲天书,张涛,窦维蓓
第一作者：Constans, J. M.,杨新辉
论文类型：会议论文
卷号：261
ISSN号：1742-6588
是否译文：否
发表时间：2011-03-09