DOU Weibei
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- Professor
- Name (Simplified Chinese):DOU Weibei
- Name (English):DOU Weibei
- Business Address:清华大学罗姆楼4-102
- Contact Information:Email: douwb@tsinghua.edu.cn； Tel: 010-62781703
- Degree:Doctoral degree
- Professional Title:Professor
- Alma Mater:电子科技大学学士、法国雷恩大学硕士、法国卡昂大学博士
- Teacher College:DZGCX
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- Selected Publications
Abnormal static and dynamic functional connectivity of resting-state fMRI in multiple system atropy
Release time:2021-12-25 Hits:
- Impact Factor:5.682
- DOI number:10.18632/aging.103676
- Journal:Aging-US
- Place of Publication:Albany NY
- Key Words:dynamic functional connectivity; graph theory attribute; multiple system atrophy; receiver operating characteristic; ventral anterior cingulate cortex.
- Abstract:In order to explore the topological alterations in functional brain networks between multiple system atrophy (MSA) patients and healthy controls (HC), a new joint analysis method of static and dynamic functional connectivity (FC) is proposed in this paper. Twenty-four MSA patients and twenty HCs were enrolled in this study. We constructed static and dynamic brain networks from resting-state fMRI data and calculated four graph theory attributes. Statistical comparisons and correlation analysis were carried out for static and dynamic FC separately before combining both cases. We found decreased local efficiency (LE) and weighted degree (WD) in cerebellum from both static and dynamic graph attributes. For static FC alone, we identified increased betweenness centrality (BC) at left dorsolateral prefrontal cortex, left Cerebellum_Crus9 and decreased WD at Vermis_6. For dynamic FC alone, decreased BC, clustering coefficients and LE at several cortical regions and cerebellum were identified. All the features had significant correlation with total UMSARS scores. Receiver operating characteristic analysis showed that dynamic features had the highest area under the curve value. Our work not only added new evidence for the underlying neurobiology and disrupted dynamic disconnection syndrome of MSA, but also proved the possibility of disease diagnosis and progression tracking using rs-fMRI.
- Co-author: Shan Ren, Weizheng Ran, Xinning Zhang, Wenyang Tian, Zhigang Chen, Weibei Dou, Zhiqun Wang,Ying Chen, Weibei Dou, Zhi Tao, Liming Chen
- First Author:Weimin Zheng, Yunxiang Ge,Zhongzhe Xiao, Ying Chen, Weibei Dou, Zhi Tao, Liming Chen
- Indexed by:Journal paper
- Correspondence Author:Zhigang Chen, Weibei Dou, Zhiqun Wang
- Volume:12
- Issue:16
- Page Number:16341-16356
- ISSN No.:1945-4589
- Translation or Not:no
- Date of Publication:2020-08-27